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KMID : 0352720060300030095
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Journal of Ginseng Research
2006 Volume.30 No. 3 p.95 ~ p.99
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Inhibitory Effect of Protopanxatriol Ginsenosides in an Oxazolone-induced Mouse Psoriatic Model
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Shin Young-Wook
Bae Eun-Ah
Han Myung-Joo
Kim Dong-Hyun
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Abstract
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When the inhibitory effect of ginsenoside (G) Re isolated from ginseng and its metabolites G-Rg1, G-F1, G-Rh1 and protopanaxatriol in mouse ear skin psoriasis stimulated by oxazolone was investigated, G-Re and its metabolites suppressed mouse ear swelling stimulated by oxazolone. Among these agents tested, G-Rh1 most potently suppressed ear swelling as well as mRNA expression of COX-2 and proinflammatory cytokines $IL-1{\beta},\;TNF-{\alpha}$ and $interferon-{\gamma}$. These findings suggest that G-Rh1 may improve chronic dermatitis and psoriasis.
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KEYWORD
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ginseng, ginsenoside Re, ginsenoside Rh1, contact dermatitis
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